Sociodemographic Characteristics of Chronic Suppurative Otitis Media In Bangladesh

Objectives: To find out sociodemographic characteristics ofChronic Suppurative Otitis Media (CSOM) in Bangladesh.Methods: It was a prospective study conducted in thedepartment of otolaryngology & Head Neck Surgery,Bangabandhu Sheikh Mujib Medical University (BSMMU) andDhaka Medical College Hospital (DMCH), Dhaka, fromSeptember 2010 to February 2011. Fifty cases were selectedby random sampling. A descriptive analysis was performed forclinical features and results were presented as mean ±standard deviation for quantitative variables and numbers(percentages) for qualitative variables.Results: In tubotympanic group, 51.61% patients belong to 21-30 years age group, whereas for atticoantral, 63.15% patientsbelong to 11-20 years age group. People living in rural area(66%) were more sufferers. Bilateral involvement is morecommon in tubotympanic type of disease & unilateralinvolvement was more common in atticoantral type of CSOM.Conclusion: CSOM is the most common chronic ear diseasein Bangladesh. It is more common in rural peoples ofyounger age group in poor socioeconomic classes with malepredominance. Medical and surgical options are limited, withside effects and risks, and sometimes are not successful ineliminating disease. There is an urgent need to focus in thearea of CSOM and hence prevent hearing loss.

Assessment of antibacterial, thrombolytic and cytotoxic potential of Cassia alata seed oil.

Cassia alata is a pan tropical shrub. It has been reported to have medicinal activities like laxative effect and active against ringworm, skin diseases and ulcer. The leaf extract of this plant has shown antibacterial activity. In this study, seed oil extracted from Cassia alata , was studied for Antibacterial, Thrombolytic and Cytotoxic activity by using in vitro techniques. Chloroform extract of the seed oil was tested for Antibacterial activity using disc diffusion method and that extract showed potent antibacterial activity against both Gram(+) and Gram(-) bacteria. DMSO extract of the seed oil was tested for Brine shrimp lethality bioassay using Brine shrimp nauplii. The LC50 of DMSO extract of Cassia alata seed oil was found to be 250μg/ml, indicates that the oil has moderate pharmacological action. The DMSO extract of the seed oil was also tested for in vitro thrombolytic activity. The extract showed reasonable thrombolytic activity against negative control (water).Further investigation on the plant is required to confirm their pharmacological activity and thereby utilizing them as useful medicinal plant.

Initial experience with 10 cases of Indiana pouch continent urinary diversion.

Indiana pouch continent urinary diversion provides patient control over elimination of urine with periods of dryness. This allows emptying of urine from the pouch by catheter at convenient intervals avoiding major metabolic abnormalities with satisfactory renal function. Detubularization of the ascending colon and caecum with tapering of the terminal ileum and tunneled tenial implants of the ureters have resulted continent cutaneous urinary reservoir. In total 10 patients were included and follow-up period was for a period of 6 months to 5 years. One year after surgery overall day and night continence rate was in 70% patients, some leakage at day and night in 30% cases and no patient developed day or night incontinence. The mean capacity of the pouch was 530 ml at 12-18 months. Pouch pressure at full capacity was 16 cm H2O at 18 months. Indiana pouch provides better attention for urinary diversion in developing countries as it is well accepted, economically more suitable and relatively easy to construct, with good results in terms of continence and reduced complications with satisfactory renal function.

Serum lipid profile in hypertensive and normotensive type II diabetes mellitus patients--a comparative study.

A comparative prospective study was done in 10 patients suffering from hypertension with type II diabetes mellitus and 10 patients suffering from type II diabetes without hypertension. The serum Lipid profile was studied on 10 healthy normotensive nondiabetic subject, on 10 patients suffering from hypertension with type II diabetes mellitus and on 10 patients suffering from type II diabetes mellitus without hypertension. In present study a significantly higher level of serum total cholesterol, triglyceride and LDL-Cholesterol concentration were observed in hypertensive type II diabetes mellitus and normotensive type II diabetes mellitus subjects in comparison to control group and serum HDL-cholesterol concentration was significantly lower in both the groups in comparison to healthy control. There was significantly increased level of serum total cholesterol (P < 0.001) and LDL-cholesterol (P < 0.001) in hypertensive type II diabetes mellitus in comparison to normotensive type II diabetes mellitus. Though serum triglyceride level was increased in hypertensive type II diabetes mellitus in comparison to normotensive type II diabetes mellitus, but it was not statistically significant. Serum HDL-cholesterol level was more in normotensive type II diabetes mellitus in comparison to hypertensive type II diabetes mellitus group but it was not statistically significant.

Serum calcium in normal pregnant women.

A prospective case-control study was done to determine any difference of serum calcium levels in pregnant women in third trimester and non-pregnant women. Serum calcium levels were determined in 30 normal non-gravid women and 30 women with normal pregnancies during third trimester with age range of 17-35 years. The mean serum calcium levels were found to be significantly lower in normal pregnant woman in third trimester than that of normal non-pregnant controls.

Clinical presentation of vitiligo.

Clinical patterns and manner of presentation of vitiligo in 200 cases have been studied. Females have a slightly higher preponderance. Majority (66%) of the patients had generalized vitiligo. Lower extremity was the most common (30%) site of involvement. Family history was positive in 24% of cases. Leukotrichia (44%) and Koebner phenomenon (30%) were the associated cutaneous findings.

Abnormal lipoprotein in uraemic patients treated conservatively and by maintenance haemodialysis.

Observations of serum lipids and lipoproteins in 35 uraemic patients treated conservatively (20 cases) and by maintenance haemodialysis (15 cases) are presented. Serum triglycerides levels of both groups (243.7 +/- 119.1 and 160.8 +/- 55.0 mg/dl) were significantly higher (p less than 0.001) and high density lipoprotein cholesterol (HDLC) levels (19.0 +/- 6.1 and 12.17 +/- 5.1 mg/dl) were significantly lower (p less than 0.001) in comparison to those in 20 controls. Agarose gel electrophoresis revealed a second, slow migrating pre-beta band in significantly higher percentage of uraemics (55% and 93.3%) as compared to controls (25%). Until the effects of uraemia and chronic haemodialysis on lipoprotein metabolism are better understood, caution should be exercised in the interpretation of HDLC levels in these patients.